"看不见的手"与科学的繁荣

“看不见的手”在科学中扮演着重要的角色,科学家个人的自利行为可以增进科学共同体的利益。要发挥“看不见的手”的神奇作用,制度的设计与安排不可或缺。唯有科学制度有效地发挥作用,科学家个人的自我目标与科学的制度目标融为一体,私人利益与公共利益和谐一致,科学才会获得真正的成功与繁荣。     

The regulation of ion channels and transporters by glycolytically derived ATP

Glycolysis is an evolutionary conserved metabolic pathway that provides small amounts of energy in the form of ATP when compared to other pathways such as oxidative phosphorylation or fatty acid oxidation. The ATP levels inside metabolically active cells are not constant and the local ATP level will depend on the site of production as well as the respective rates of ATP production, diffusion and consumption. Membrane ion transporters (pumps, exchangers and channels) are located at sites distal to the major sources of ATP formation (the mitochondria). We review evidence that the glycolytic complex is associated with membranes; both at the plasmalemma and with membranes of the endo/sarcoplasmic reticular network. We examine the evidence for the concept that many of the ion transporters are regulated preferentially by the glycolytic process. These include the Na⁺/K⁺-ATPase, the H⁺-ATPase, various types of Ca²⁺-ATPases, the Na⁺/H⁺ exchanger, the ATP-sensitive K⁺ channel, cation channels, Na⁺ channels, Ca²⁺ channels and other channels involved in intracellular Ca²⁺ homeostasis. Regulation of these pumps, exchangers and ion channels by the glycolytic process has important consequences in a variety of physiological and pathophysiological processes, and a better understanding of this mode of regulation may have important consequences for developing future strategies in combating disease and developing novel therapeutic approaches. Received 20 July 2007; received after revision 30 July 2007; accepted 17 August 2007     

现代工程图学教学方法及教学手段的研究与实践

根据现代工程图学课程特点及学生学习本门课程存在的问题,通过对传统教学和多媒体教学的利弊分析,提出了传统教学与多媒体教学有机结合是现代工程图学课堂教学有效的教学模式的观点,介绍了适应课堂教学的多媒体课件的制作方法.同时,提出了网络教学是远程学习、选修课学习和课外学习有效的教学模式的观点,介绍了网络教学的特点、教学方法及现代工程图学网络教学系统的内容.     

山西省部分非试点县农村新型合作医疗的调查

建立推广新型合作医疗的要点是:加大宣传力度;加强领导,发挥政府主导作用;强化监督,加强管理,确保基金安全平稳运行;创新服务机制,完善便民措施,实现服务管理一体化。     

浅论Simulink在抗震教学中的应用

建筑结构抗震教学中的难点之一在于运动微分方程的求解,同时,该课程存在着学时少、内容多的矛盾。本文在分析Simulink软件的主要特征的基础上,提出将该软件引入抗震多媒体教学中能起到积极作用。     

知识挖掘在电信业客户关系管理中的应用

介绍了基于知识挖掘的电信业客户关系管理,分别从潜在用户、业务流程、客户行为角度探讨了知识挖掘在客户关系管理中的应用。     

大学语文教材对象语言的选择与教材编写

本文从教材语言的特点来探讨大学语文教材对象语言的选择与教材编写问题。首先，结合教材语言的基础性与功能性特点来分析大学语文教材建设过程中存在的一些问题；其次，结合教材语言的有线性、有序性、通用性与专业性特点来具体探讨教材对象语言的选择问题；最后，结合大学语文教材语言的特点和大学语文课程的定位来谈谈大学语文教材编写的发展方向。     

Multiple MIPS 4Kc cores based interrupt controller design and its implementation on HDTV SoC platform

A multiple MIPS 4Kc processor cores based interrupt processing system is introduced. The interrupt controller plays a key role in the high definition television （HDTV） system-on-a-chip （SoC） platform, especially when it is a multiple processor system. Based on a general introduction to the whole HDTV SoC platform, a layered interrupt controller and its implementation are discussed in detail. The proposed scheme was implemented in our FPGA verification board. The results indicate that our scheme is reliable and efficient. Meanwhile, as a functional intellectual property （IP）, the interrupt controller has reusability and expandability with the layered structure.